Am J Cancer Res 2011;1(6):763-772
Review Article
Interactions between Hsp90 and oncogenic viruses implications for viral cancer
therapeutics
Michael R. DeFee, Zhiqiang Qin, Lu Dai, Jennifer S. Isaacs, Chris H. Parsons
Departments of Microbiology and Immunology, Craniofacial Biology, Medicine, Regenerative Medicine and Cell Biology, and
Pharmacology, Medical University of South Carolina, 86 Jonathan Lucas St., Charleston, SC 29425, USA.
Received May 18, 2011; accepted May 31, 2011; Epub June 5, 2011; Published June 30, 2011
Abstract: Oncogenic viruses are the etiologic agents for a significant fraction of all human malignancies, but effective therapies
and preventative strategies are lacking for the majority of virus-associated tumors. Targeting of virus-induced signal transduction
or virus-host protein interactions may offer novel therapeutic strategies for viral cancers. Heat shock protein 90 (Hsp90) is a well-
characterized molecular chaperone integral to cancer pathogenesis, including regulation of signal transduction, transcriptional
activation and oncogenic protein stabilization and neovascularization—pathogenic elements relevant to viral cancer
pathogenesis. This review will summarize mechanistic concepts involving regulation of viral oncogenesis by both intracellular
and extracellular Hsp90, as well as current therapeutic implications of these data. (AJCR0000069).
Keywords: KSHV, heat shock protein, signal transduction, cancer, viruses
Full Text PDF
Address all correspondence to:
Chris H. Parsons, PhD
Medical University of South Carolina
Hollings Cancer Center
Room 512G, 86 Jonathan Lucas St.
Charleston, SC 29425.
Tel: (843)-792-3644. Fax: (843)-792-6680
E-mail: parsonch@musc.edu
Review Article
Interactions between Hsp90 and oncogenic viruses implications for viral cancer
therapeutics
Michael R. DeFee, Zhiqiang Qin, Lu Dai, Jennifer S. Isaacs, Chris H. Parsons
Departments of Microbiology and Immunology, Craniofacial Biology, Medicine, Regenerative Medicine and Cell Biology, and
Pharmacology, Medical University of South Carolina, 86 Jonathan Lucas St., Charleston, SC 29425, USA.
Received May 18, 2011; accepted May 31, 2011; Epub June 5, 2011; Published June 30, 2011
Abstract: Oncogenic viruses are the etiologic agents for a significant fraction of all human malignancies, but effective therapies
and preventative strategies are lacking for the majority of virus-associated tumors. Targeting of virus-induced signal transduction
or virus-host protein interactions may offer novel therapeutic strategies for viral cancers. Heat shock protein 90 (Hsp90) is a well-
characterized molecular chaperone integral to cancer pathogenesis, including regulation of signal transduction, transcriptional
activation and oncogenic protein stabilization and neovascularization—pathogenic elements relevant to viral cancer
pathogenesis. This review will summarize mechanistic concepts involving regulation of viral oncogenesis by both intracellular
and extracellular Hsp90, as well as current therapeutic implications of these data. (AJCR0000069).
Keywords: KSHV, heat shock protein, signal transduction, cancer, viruses
Full Text PDF
Address all correspondence to:
Chris H. Parsons, PhD
Medical University of South Carolina
Hollings Cancer Center
Room 512G, 86 Jonathan Lucas St.
Charleston, SC 29425.
Tel: (843)-792-3644. Fax: (843)-792-6680
E-mail: parsonch@musc.edu
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American Journal of Cancer Research
| ISSN: 2156-6976 |