Am J Cancer Res 2011;1(7):845-851
Review Article
Base excision repair targets for cancer therapy
Grigory L. Dianov
Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Old Road Campus Research
Building, Roosevelt Drive, Oxford OX3 7DQ, UK
Received July 5, 2011; accepted August 3, 2011; Epub August 12, 2011; Published August 30, 2011
Abstract: Cellular DNA repair is a frontline system that is responsible for maintaining genome integrity and thus preventing
premature aging and cancer by repairing DNA lesions and strand breaks caused by endogenous and exogenous mutagens.
However, it is also the principal cellular system in cancer cells that counteracts the killing effect of the major cancer treatments
e.g. chemotherapy and ionizing radiation. The major goal of this review is to critically exam the base excision repair pathway and
mechanisms regulating base excision repair capacity as a potential targets for improving cancer therapy. (AJCR0000076).
Keywords: DNA repair, base excision, chemotherapy, ionizing radiation, cancer therapy
Full Text PDF
Address all correspondence to:
Dr. Grigory L. Dianov
Gray Institute for Radiation Oncology and Biology
Department of Oncology, University of Oxford
Old Road Campus Research Building
Roosevelt Drive, Oxford OX3 7DQ, UK
E-mail: grigory.dianov@rob.ox.ac.uk
Review Article
Base excision repair targets for cancer therapy
Grigory L. Dianov
Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Old Road Campus Research
Building, Roosevelt Drive, Oxford OX3 7DQ, UK
Received July 5, 2011; accepted August 3, 2011; Epub August 12, 2011; Published August 30, 2011
Abstract: Cellular DNA repair is a frontline system that is responsible for maintaining genome integrity and thus preventing
premature aging and cancer by repairing DNA lesions and strand breaks caused by endogenous and exogenous mutagens.
However, it is also the principal cellular system in cancer cells that counteracts the killing effect of the major cancer treatments
e.g. chemotherapy and ionizing radiation. The major goal of this review is to critically exam the base excision repair pathway and
mechanisms regulating base excision repair capacity as a potential targets for improving cancer therapy. (AJCR0000076).
Keywords: DNA repair, base excision, chemotherapy, ionizing radiation, cancer therapy
Full Text PDF
Address all correspondence to:
Dr. Grigory L. Dianov
Gray Institute for Radiation Oncology and Biology
Department of Oncology, University of Oxford
Old Road Campus Research Building
Roosevelt Drive, Oxford OX3 7DQ, UK
E-mail: grigory.dianov@rob.ox.ac.uk
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American Journal of Cancer Research
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