Am J Cancer Res 2011;1(3):275-300
Review Article
Squamous cell carcinoma – similarities and differences among anatomical sites
Wusheng Yan, Ignacio I. Wistuba, Michael R. Emmert-Buck, Heidi S. Erickson
Pathogenetics Unit, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health,
Bethesda, MD 20892, USA; Thoracic Molecular Pathology Lab, Departments of Pathology and Thoracic/Head & Neck Medical
Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Thoracic Molecular Pathology Lab,
Department of Thoracic/Head & Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030,
USA.
Received December 20, 2010; accepted December, 2010; Epub December, 2010; Published January 1, 2011
Abstract: Vaccines are one of the main arms of preventive medicine. Recently a large series of experiments with cancer-prone
genetically engineered mice have shown that preventive vaccines are also extremely efficacious inhibitors of the progression of
carcinogenesis. Early vaccination affords significant and persistent protection, whereas its efficacy fades when neoplastic
lesions become more advanced. Our current attempts to use combination strategies and technological advances to make
vaccines effective in cancer prevention able to cure more advanced stages of cancer lesions are based on the temporary and
systemic Treg removal, the preparation of new bimodular plasmids for DNA vaccination and the search for fresh target
oncoantigens. (AJCR0000023).
Keywords: Squamous cell carcinoma (SCC), non-melanoma skin cancer (NMSC), head and neck squamous cell carcinomas
(HNSCC), esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC), epidemiology, risk factors,
molecular characteristics, prognostic markers, targeted therapy
Full Text PDF
Address all correspondence to:
Dr. Heidi S. Erickson
Department of Thoracic / Head & Neck Medical Oncology
UT MD Anderson Cancer Center
Houston, Texas 77030, USA.
E-mail: HSErickson@mdanderson.org
Dr. Michael R. Emmert-Buck
Pathogenetics Unit, Laboratory of Pathology
Center for Cancer Research, National Cancer Institute
National Institutes of Health
Bethesda, Maryland 20892.
E-mail: mbuck@helix.nih.gov
Review Article
Squamous cell carcinoma – similarities and differences among anatomical sites
Wusheng Yan, Ignacio I. Wistuba, Michael R. Emmert-Buck, Heidi S. Erickson
Pathogenetics Unit, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health,
Bethesda, MD 20892, USA; Thoracic Molecular Pathology Lab, Departments of Pathology and Thoracic/Head & Neck Medical
Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Thoracic Molecular Pathology Lab,
Department of Thoracic/Head & Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030,
USA.
Received December 20, 2010; accepted December, 2010; Epub December, 2010; Published January 1, 2011
Abstract: Vaccines are one of the main arms of preventive medicine. Recently a large series of experiments with cancer-prone
genetically engineered mice have shown that preventive vaccines are also extremely efficacious inhibitors of the progression of
carcinogenesis. Early vaccination affords significant and persistent protection, whereas its efficacy fades when neoplastic
lesions become more advanced. Our current attempts to use combination strategies and technological advances to make
vaccines effective in cancer prevention able to cure more advanced stages of cancer lesions are based on the temporary and
systemic Treg removal, the preparation of new bimodular plasmids for DNA vaccination and the search for fresh target
oncoantigens. (AJCR0000023).
Keywords: Squamous cell carcinoma (SCC), non-melanoma skin cancer (NMSC), head and neck squamous cell carcinomas
(HNSCC), esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC), epidemiology, risk factors,
molecular characteristics, prognostic markers, targeted therapy
Full Text PDF
Address all correspondence to:
Dr. Heidi S. Erickson
Department of Thoracic / Head & Neck Medical Oncology
UT MD Anderson Cancer Center
Houston, Texas 77030, USA.
E-mail: HSErickson@mdanderson.org
Dr. Michael R. Emmert-Buck
Pathogenetics Unit, Laboratory of Pathology
Center for Cancer Research, National Cancer Institute
National Institutes of Health
Bethesda, Maryland 20892.
E-mail: mbuck@helix.nih.gov
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American Journal of Cancer Research
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