Am J Cancer Res 2011;1(3):390-412
Review Article
Radiation-induced tumor neoantigens: imaging and therapeutic implications
Christopher D. Corso, Arif Ali, Roberto Diaz
Emory University School of Medicine, Atlanta, GA 30322; Emory University Department of Radiation Oncology, Atlanta, GA 30322,
USA.
Received January 11, 2011; accepted January 23, 2011; Epub January 25, 2011; Published February 15, 2011
Abstract: Exposure of tumor cells to ionizing radiation (IR) is widely known to induce a number of cellular changes. One way that
IR can affect tumor cells is through the development of neoantigens which are new molecules that tumor cells express at the cell
membrane following some insult or change to the cell. There have been numerous reports in the literature of changes in both
tumor and tumor vasculature cell surface molecule expression following treatment with IR. The usefulness of neoantigens for
imaging and therapeutic applications lies in the fact that they are differentially expressed on the surface of irradiated tumor cells
to a greater extent than on normal tissues. This differential expression provides a mechanism by which tumor cells can be
“marked” by radiation for further targeting. Drug delivery vehicles or imaging agents conjugated to ligands that recognize and
interact with the neoantigens can help to improve tumor-specific targeting and reduce systemic toxicity with cancer drugs. This
article provides a review of the molecules that have been reported to be expressed on the surface of tumor cells in response to
IR either in vivo or in vitro. Additionally, we provide a discussion of some of the methods used in the identification of these
antigens and applications for their use in drug delivery and imaging.(AJCR0000029).
Keywords: Radiation-induced neoantigens, targeted therapy, nanoparticles, ionizing radiation
Full Text PDF
Address all correspondence to:
Dr. Roberto Diaz,
Department of Radiation Oncology, Emory University
School of Medicine, and Winship Cancer Institute of
Emory University
Suite A1300, 1365 Clifton Road, NE, Atlanta, GA 30322, USA.
Tel: 404-778-3669. Fax: 404-778-1750.
E-mail: roberto.diaz@emory.edu
Review Article
Radiation-induced tumor neoantigens: imaging and therapeutic implications
Christopher D. Corso, Arif Ali, Roberto Diaz
Emory University School of Medicine, Atlanta, GA 30322; Emory University Department of Radiation Oncology, Atlanta, GA 30322,
USA.
Received January 11, 2011; accepted January 23, 2011; Epub January 25, 2011; Published February 15, 2011
Abstract: Exposure of tumor cells to ionizing radiation (IR) is widely known to induce a number of cellular changes. One way that
IR can affect tumor cells is through the development of neoantigens which are new molecules that tumor cells express at the cell
membrane following some insult or change to the cell. There have been numerous reports in the literature of changes in both
tumor and tumor vasculature cell surface molecule expression following treatment with IR. The usefulness of neoantigens for
imaging and therapeutic applications lies in the fact that they are differentially expressed on the surface of irradiated tumor cells
to a greater extent than on normal tissues. This differential expression provides a mechanism by which tumor cells can be
“marked” by radiation for further targeting. Drug delivery vehicles or imaging agents conjugated to ligands that recognize and
interact with the neoantigens can help to improve tumor-specific targeting and reduce systemic toxicity with cancer drugs. This
article provides a review of the molecules that have been reported to be expressed on the surface of tumor cells in response to
IR either in vivo or in vitro. Additionally, we provide a discussion of some of the methods used in the identification of these
antigens and applications for their use in drug delivery and imaging.(AJCR0000029).
Keywords: Radiation-induced neoantigens, targeted therapy, nanoparticles, ionizing radiation
Full Text PDF
Address all correspondence to:
Dr. Roberto Diaz,
Department of Radiation Oncology, Emory University
School of Medicine, and Winship Cancer Institute of
Emory University
Suite A1300, 1365 Clifton Road, NE, Atlanta, GA 30322, USA.
Tel: 404-778-3669. Fax: 404-778-1750.
E-mail: roberto.diaz@emory.edu
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American Journal of Cancer Research
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