Am J Cancer Res 2012;2(1):65-74
Review Article
Understanding the role of miRNA in regulating NF-κB in blood cancer
Stuart A. Rushworth, Megan Y. Murray, Lawrence N. Barrera, Sally-Anne Heasman, Lyubov Zaitseva and David J. MacEwan
School of Pharmacy, University of East Anglia, Norwich NR4 7TJ, United Kingdom
Received September 23, 2011; accepted November 15, 2011; Epub November 21, 2011; Published January 1,
2012
Abstract: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by binding to complementary
sequences in mRNAs encoding downstream target genes. A large variety of cellular processes, including differentiation,
development, apoptosis and cell cycle progression, are dependent on miRNA-mediated suppression of gene expression for
their regulation. As such, it is unsurprising that these small RNA molecules are associated with signaling networks that are
often altered in various diseases, including many blood cancers. One such network is the nuclear factor-κB (NF-κB) pathways
that universally stimulate transcription of proteins which generally promote cell survival, inhibit apoptosis, allow cellular growth,
induce angiogenesis and generate many pro-inflammatory responses. The NF-κB signalling pathway is often constitutively
activated in blood cell cancers including myelodysplastic syndrome (MDS), acute myeloid leukaemia (AML), acute lymphocytic
leukaemia (ALL), chronic myeloid leukaemia (CML), chronic lymphocytic leukaemia (CLL), lymphomas and in multiple myeloma
(MM). This review focuses on the function of miRNAs that directly target NF-κB signaling cascade. Recent findings that connect
this pathway through various miRNA families to human blood cancers are reviewed, and support for using miRNA-based
therapy as a novel method to counteract this tumour-promoting signalling event is discussed.(AJCR0000089).
Keywords: Leukemia, NF-κB, microRNA, gene regulation, apoptosis
Full Text PDF
Address all correspondence to:
Dr. David J. MacEwan
School of Pharmacy
University of East Anglia
Norwich, NR4 7TJ
United Kingdom
Tel: +44 (0)1603 592005
Fax: +44 (0)1603 452003
E-mail: d.macewan@uea.ac.uk
Review Article
Understanding the role of miRNA in regulating NF-κB in blood cancer
Stuart A. Rushworth, Megan Y. Murray, Lawrence N. Barrera, Sally-Anne Heasman, Lyubov Zaitseva and David J. MacEwan
School of Pharmacy, University of East Anglia, Norwich NR4 7TJ, United Kingdom
Received September 23, 2011; accepted November 15, 2011; Epub November 21, 2011; Published January 1,
2012
Abstract: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by binding to complementary
sequences in mRNAs encoding downstream target genes. A large variety of cellular processes, including differentiation,
development, apoptosis and cell cycle progression, are dependent on miRNA-mediated suppression of gene expression for
their regulation. As such, it is unsurprising that these small RNA molecules are associated with signaling networks that are
often altered in various diseases, including many blood cancers. One such network is the nuclear factor-κB (NF-κB) pathways
that universally stimulate transcription of proteins which generally promote cell survival, inhibit apoptosis, allow cellular growth,
induce angiogenesis and generate many pro-inflammatory responses. The NF-κB signalling pathway is often constitutively
activated in blood cell cancers including myelodysplastic syndrome (MDS), acute myeloid leukaemia (AML), acute lymphocytic
leukaemia (ALL), chronic myeloid leukaemia (CML), chronic lymphocytic leukaemia (CLL), lymphomas and in multiple myeloma
(MM). This review focuses on the function of miRNAs that directly target NF-κB signaling cascade. Recent findings that connect
this pathway through various miRNA families to human blood cancers are reviewed, and support for using miRNA-based
therapy as a novel method to counteract this tumour-promoting signalling event is discussed.(AJCR0000089).
Keywords: Leukemia, NF-κB, microRNA, gene regulation, apoptosis
Full Text PDF
Address all correspondence to:
Dr. David J. MacEwan
School of Pharmacy
University of East Anglia
Norwich, NR4 7TJ
United Kingdom
Tel: +44 (0)1603 592005
Fax: +44 (0)1603 452003
E-mail: d.macewan@uea.ac.uk
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American Journal of Cancer Research
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