Am J Cancer Res 2012;2(1):93-103
Original Article
Molecular signature and pathway analysis of human primary squamous and
adenocarcinoma lung cancers
Nikolai Daraselia, Yipeng Wang, Adam Budoff, Alexander Lituev, Olga Potapova, Gordon Vansant, Joseph Monforte, Ilya Mazo,
Valeria S.Ossovskaya
Ariadne Inc., Rockville, MD, USA; AltheaDx, San Diego, CA, USA; Cureline Inc., South San Francisco, CA, USA; BiPar Sciences,
Inc. (subsidiary of Sanofi), South San Francisco, CA, USA.
Received September 29, 2011; accepted October 22, 2011; Epub November 19, 2011; Published January 1, 2012
Abstract: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, with a poor response to chemotherapy
and low survival rate. This unfavorable treatment response is likely to derive from both late diagnosis and from complex,
incompletely understood biology, and heterogeneity among NSCLC subtypes. To define the relative contributions of major
cellular pathways to the biogenesis of NSCLC and highlight major differences between NSCLC subtypes, we studied the
molecular signatures of lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC), based on analysis of gene
expression and comparison of tumor samples with normal lung tissue. Our results suggest the existence of specific molecular
networks and subtype-specific differences between lung ADC and SCC subtypes, mostly found in cell cycle, DNA repair, and
metabolic pathways. However, we also observed similarities across major gene interaction networks and pathways in ADC and
SCC. These data provide a new insight into the biology of ADC and SCC and can be used to explore novel therapeutic
interventions in lung cancer chemoprevention and treatment. (AJCR0000091).
Keywords: NSCLC, adenocarcinoma, squamous cell carcinoma, molecular signature, gene expression, pathway
Full Text PDF
Address all correspondence to:
Dr. Valeria S. Ossovskaya, BiPar Sciences, Inc. (subsidiary of Sanofi)
400 Oyster Point Blvd., Suite 200, South San Francisco, CA 94080, USA.
Tel. (650) 615-7019; Fax: (650) 615-7005
E-mail: valeria.ossovskaya@sanofi-aventis.com
Original Article
Molecular signature and pathway analysis of human primary squamous and
adenocarcinoma lung cancers
Nikolai Daraselia, Yipeng Wang, Adam Budoff, Alexander Lituev, Olga Potapova, Gordon Vansant, Joseph Monforte, Ilya Mazo,
Valeria S.Ossovskaya
Ariadne Inc., Rockville, MD, USA; AltheaDx, San Diego, CA, USA; Cureline Inc., South San Francisco, CA, USA; BiPar Sciences,
Inc. (subsidiary of Sanofi), South San Francisco, CA, USA.
Received September 29, 2011; accepted October 22, 2011; Epub November 19, 2011; Published January 1, 2012
Abstract: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, with a poor response to chemotherapy
and low survival rate. This unfavorable treatment response is likely to derive from both late diagnosis and from complex,
incompletely understood biology, and heterogeneity among NSCLC subtypes. To define the relative contributions of major
cellular pathways to the biogenesis of NSCLC and highlight major differences between NSCLC subtypes, we studied the
molecular signatures of lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC), based on analysis of gene
expression and comparison of tumor samples with normal lung tissue. Our results suggest the existence of specific molecular
networks and subtype-specific differences between lung ADC and SCC subtypes, mostly found in cell cycle, DNA repair, and
metabolic pathways. However, we also observed similarities across major gene interaction networks and pathways in ADC and
SCC. These data provide a new insight into the biology of ADC and SCC and can be used to explore novel therapeutic
interventions in lung cancer chemoprevention and treatment. (AJCR0000091).
Keywords: NSCLC, adenocarcinoma, squamous cell carcinoma, molecular signature, gene expression, pathway
Full Text PDF
Address all correspondence to:
Dr. Valeria S. Ossovskaya, BiPar Sciences, Inc. (subsidiary of Sanofi)
400 Oyster Point Blvd., Suite 200, South San Francisco, CA 94080, USA.
Tel. (650) 615-7019; Fax: (650) 615-7005
E-mail: valeria.ossovskaya@sanofi-aventis.com
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American Journal of Cancer Research
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