Am J Cancer Res 2012;2(3):286-297
Review Article
Inflammation in thyroid oncogenesis
Federica Liotti, Carla Visciano, Rosa Marina Melillo
Dipartimento di Biologia e Patologia Cellulare e Molecolare/Istituto di Endocrinologia ed Oncologia Sperimentale del CNR ”G.
Salvatore", Facoltà di Scienze Biotecnologiche dell’Università di Napoli “Federico II, 80131 Naples, Italy
Received March 26, 2012; accepted April 16, 2012; Epub April 21, 2012; Published May 15, 2012
Abstract: It is commonly accepted that cancer is linked to inflammation. The possible mechanisms by which inflammation can
contribute to carcinogenesis include induction of genomic instability, alterations in epigenetic events and subsequent
inappropriate gene expression, enhanced proliferation of initiated cells, resistance to apoptosis, aggressive tumor
neovascularization, invasion through tumor-associated basement membrane and metastasis. Inflammation also affects
immune surveillance and responses to therapy. In this review, we overview the current understanding of different aspects of
thyroid cancer and inflammation. Several studies have strongly suggested an increased risk of PTC in patients with Hashimoto's
thyroiditis (HT), the most common autoimmune disease in thyroid cancer. Furthermore, an intense immune infiltrate is often
associated with papillary thyroid carcinoma (PTC) and might play a critical role in the regulation of carcinogenesis and in
carcinoma progression. The characterization of the most relevant inflammatory pathways of cancer-related inflammation (CRI) is
instrumental for the identification of new target molecules that could lead to improved diagnosis and treatment. (AJCR00000111).
Keywords: Cancer-related inflammation, thyroid cancer, inflammatory cell, chemokine
Address all correspondence to:
Dr. Rosa Marina Melillo
DBPCM/IEOS, Via S Pansini, 5, 80131
Naples, Italy.
Tel: 39-0817463603; Fax: 39-0817463603
E-mail: rosmelil@unina.it
Review Article
Inflammation in thyroid oncogenesis
Federica Liotti, Carla Visciano, Rosa Marina Melillo
Dipartimento di Biologia e Patologia Cellulare e Molecolare/Istituto di Endocrinologia ed Oncologia Sperimentale del CNR ”G.
Salvatore", Facoltà di Scienze Biotecnologiche dell’Università di Napoli “Federico II, 80131 Naples, Italy
Received March 26, 2012; accepted April 16, 2012; Epub April 21, 2012; Published May 15, 2012
Abstract: It is commonly accepted that cancer is linked to inflammation. The possible mechanisms by which inflammation can
contribute to carcinogenesis include induction of genomic instability, alterations in epigenetic events and subsequent
inappropriate gene expression, enhanced proliferation of initiated cells, resistance to apoptosis, aggressive tumor
neovascularization, invasion through tumor-associated basement membrane and metastasis. Inflammation also affects
immune surveillance and responses to therapy. In this review, we overview the current understanding of different aspects of
thyroid cancer and inflammation. Several studies have strongly suggested an increased risk of PTC in patients with Hashimoto's
thyroiditis (HT), the most common autoimmune disease in thyroid cancer. Furthermore, an intense immune infiltrate is often
associated with papillary thyroid carcinoma (PTC) and might play a critical role in the regulation of carcinogenesis and in
carcinoma progression. The characterization of the most relevant inflammatory pathways of cancer-related inflammation (CRI) is
instrumental for the identification of new target molecules that could lead to improved diagnosis and treatment. (AJCR00000111).
Keywords: Cancer-related inflammation, thyroid cancer, inflammatory cell, chemokine
Address all correspondence to:
Dr. Rosa Marina Melillo
DBPCM/IEOS, Via S Pansini, 5, 80131
Naples, Italy.
Tel: 39-0817463603; Fax: 39-0817463603
E-mail: rosmelil@unina.it
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American Journal of Cancer Research
| ISSN: 2156-6976 |