Am J Cancer Res 2012;2(4):357-371
Review Article
Oncogenic signaling by tyrosine kinases of the SRC family in advanced
colorectal cancer
Audrey Sirvent, Christine Benistant, Serge Roche
CNRS UMR5237, University of Montpellier 1 and 2, CRBM, 34000 Montpellier, France
Received May 10, 2012; accepted May 31, 2012; Epub June 28, 2012; Published July 15, 2012
Abstract: The non-receptor tyrosine kinases of the SRC family (SFK) play important roles in signal transduction induced by a
large variety of extracellular stimuli, including growth factors and Integrins. When deregulated, SFKs show oncogenic activity, as
originally reported for v-Src, the transforming product of the avian retrovirus RSV, and then, in many human cancers, particularly
colorectal cancer (CRC). In CRC, SFK deregulation largely occurs in the absence of mutations of the corresponding genes, but
the underlying molecular mechanisms involved are still unclear. In addition to a role in early tumor progression, SFK
deregulation may also be important in advanced CRC, as suggested by the association between increased SFK activity and
poor clinical outcome. However, SFK contribution to CRC metastasis formation is still poorly documented. Here, we will review
recent findings that broaden our understanding of the mechanisms underlying SFK deregulation and signaling in advanced
CRC. We will also discuss the implication of these observations for SFK-based therapy in metastatic CRC. (AJCR0000121).
Keywords: Non-receptor tyrosine kinases, signal transduction, colorectal cancer (CRC), early tumor progression, advanced
CRC
Address all correspondence to:
Dr. Serge Roche
CRBM, UMR5237
1919 route de Mende
34293 Montpellier Cedex 05, France.
Tel: +33 434359520; Fax: 33 4 34 35 94 10
E-mail: Serge.Roche@crbm.cnrs.fr
Review Article
Oncogenic signaling by tyrosine kinases of the SRC family in advanced
colorectal cancer
Audrey Sirvent, Christine Benistant, Serge Roche
CNRS UMR5237, University of Montpellier 1 and 2, CRBM, 34000 Montpellier, France
Received May 10, 2012; accepted May 31, 2012; Epub June 28, 2012; Published July 15, 2012
Abstract: The non-receptor tyrosine kinases of the SRC family (SFK) play important roles in signal transduction induced by a
large variety of extracellular stimuli, including growth factors and Integrins. When deregulated, SFKs show oncogenic activity, as
originally reported for v-Src, the transforming product of the avian retrovirus RSV, and then, in many human cancers, particularly
colorectal cancer (CRC). In CRC, SFK deregulation largely occurs in the absence of mutations of the corresponding genes, but
the underlying molecular mechanisms involved are still unclear. In addition to a role in early tumor progression, SFK
deregulation may also be important in advanced CRC, as suggested by the association between increased SFK activity and
poor clinical outcome. However, SFK contribution to CRC metastasis formation is still poorly documented. Here, we will review
recent findings that broaden our understanding of the mechanisms underlying SFK deregulation and signaling in advanced
CRC. We will also discuss the implication of these observations for SFK-based therapy in metastatic CRC. (AJCR0000121).
Keywords: Non-receptor tyrosine kinases, signal transduction, colorectal cancer (CRC), early tumor progression, advanced
CRC
Address all correspondence to:
Dr. Serge Roche
CRBM, UMR5237
1919 route de Mende
34293 Montpellier Cedex 05, France.
Tel: +33 434359520; Fax: 33 4 34 35 94 10
E-mail: Serge.Roche@crbm.cnrs.fr
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American Journal of Cancer Research
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