Am J Cancer Res 2012;2(5):529-539
Review Article
Regulation of cancer stem cell activities by tumor-associated macrophages
Masahisa Jinushi, Muhammad Baghdadi, Shigeki Chiba, Hironori Yoshiyama
Research Center for Infection-associated cancer, Institute for Genetic Medicine, Hokkaido University
Received June 8, 2012; accepted July 5, 2012; Epub August 20, 2012; Published September 15, 2012
Abstract: Recent studies revealed that tumor-associated macrophages play a decisive role in the regulation of tumor
progression by manipulating tumor oncogenesis, angiogenesis and immune functions within tumor microenvironments.
However, the role of cancer stem cells in the tumorigenic activities of tumor-associated macrophages during the course of
transformation and treatment remains largely unknown. Recent studies have clarified the functional aspects of tumor-associated
macrophages in the regulation of the tumorigenic activities and anticancer drug responsiveness of cancer stem cells through
complex networks formed by distinct sets of cytokines, chemokines and growth factors. In this article we discuss recent
advances and future perspectives regarding the molecular interplay between cancer stem cells and tumor-associated
macrophages and provide future perspective about the therapeutic implication against treatment-resistant variants of cancer.
(AJCR0000130).
Keywords: Cancer stem cells, tumor associated macrophages, tumor microenvironments, MFG-E8, IL-6, TIM-3, M-CSF
Address all correspondence to:
Dr. Masahisa Jinushi
Research Center for Infection-associated cancer
Institute for Genetic Medicine, Hokkaido University
Hokkaido, Japan.
Tel: +81-11-706-6073; Fax: +81-11-706-6071
E-mail: jinushi@igm.hokudai.ac.jp
Review Article
Regulation of cancer stem cell activities by tumor-associated macrophages
Masahisa Jinushi, Muhammad Baghdadi, Shigeki Chiba, Hironori Yoshiyama
Research Center for Infection-associated cancer, Institute for Genetic Medicine, Hokkaido University
Received June 8, 2012; accepted July 5, 2012; Epub August 20, 2012; Published September 15, 2012
Abstract: Recent studies revealed that tumor-associated macrophages play a decisive role in the regulation of tumor
progression by manipulating tumor oncogenesis, angiogenesis and immune functions within tumor microenvironments.
However, the role of cancer stem cells in the tumorigenic activities of tumor-associated macrophages during the course of
transformation and treatment remains largely unknown. Recent studies have clarified the functional aspects of tumor-associated
macrophages in the regulation of the tumorigenic activities and anticancer drug responsiveness of cancer stem cells through
complex networks formed by distinct sets of cytokines, chemokines and growth factors. In this article we discuss recent
advances and future perspectives regarding the molecular interplay between cancer stem cells and tumor-associated
macrophages and provide future perspective about the therapeutic implication against treatment-resistant variants of cancer.
(AJCR0000130).
Keywords: Cancer stem cells, tumor associated macrophages, tumor microenvironments, MFG-E8, IL-6, TIM-3, M-CSF
Address all correspondence to:
Dr. Masahisa Jinushi
Research Center for Infection-associated cancer
Institute for Genetic Medicine, Hokkaido University
Hokkaido, Japan.
Tel: +81-11-706-6073; Fax: +81-11-706-6071
E-mail: jinushi@igm.hokudai.ac.jp
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American Journal of Cancer Research
| ISSN: 2156-6976 |