Am J Cancer Res 2012;2(5):589-597
Review Article
Histone modifications and cancer: biomarkers of prognosis?
Yana Chervona, Max Costa
Department of Environmental Medicine, New York University Langone Medical Center, Tuxedo, New York 10987, USA
Received July 31, 2012; Accepted August 17, 2012; Epub August 20, 2012; Published September 15, 2012
Abstract: Epigenetic dysregulation is being increasingly recognized as a hallmark of cancer. Post-translational modifications of
histones, in particular, are known to play important roles gene expression alterations in cancer development and progression.
Given their key involvement in the various stages of carcinogenesis, histone modifications are also being explored as potential
biomarkers of disease progression and prognosis. This review will therefore discuss the role of histone modifications in cancer
biology and will explore their prognostic potential. (AJCR0000140).
Keywords: Histone modifications, cancer, biomarkers, prognosis
Address all correspondence to:
Dr. Max Costa
Department of Environmental Medicine
New York University Langone Medical Center
Tuxedo, New York 10987, USA.
Tel: (845)-731-3515; Fax: (845)-731-2118
E-mail: Max.Costa@nyumc.org
Review Article
Histone modifications and cancer: biomarkers of prognosis?
Yana Chervona, Max Costa
Department of Environmental Medicine, New York University Langone Medical Center, Tuxedo, New York 10987, USA
Received July 31, 2012; Accepted August 17, 2012; Epub August 20, 2012; Published September 15, 2012
Abstract: Epigenetic dysregulation is being increasingly recognized as a hallmark of cancer. Post-translational modifications of
histones, in particular, are known to play important roles gene expression alterations in cancer development and progression.
Given their key involvement in the various stages of carcinogenesis, histone modifications are also being explored as potential
biomarkers of disease progression and prognosis. This review will therefore discuss the role of histone modifications in cancer
biology and will explore their prognostic potential. (AJCR0000140).
Keywords: Histone modifications, cancer, biomarkers, prognosis
Address all correspondence to:
Dr. Max Costa
Department of Environmental Medicine
New York University Langone Medical Center
Tuxedo, New York 10987, USA.
Tel: (845)-731-3515; Fax: (845)-731-2118
E-mail: Max.Costa@nyumc.org
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American Journal of Cancer Research
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