Am J Cancer Res 2013;3(1):21-33
Review Article
Obesity-driven inflammation and cancer risk: role of myeloid derived
suppressor cells and alternately activated macrophages
Derick Okwan-Duodu, Guillermo E Umpierrez, Otis W Brawley, Roberto Diaz
Department of Radiation Oncology, Medicine, Hematology and Medical Oncology, Emory University School of Medicine, Atlanta
GA USA 30322
Received December 5, 2012; Accepted December 23, 2012; Epub January 18, 2013; Published January 25, 2013
Abstract: During carcinogenesis, tumors induce dysfunctional development of hematopoietic cells. Myeloid lineage cells, in the
form of myeloid derived suppressor cells (MDSCs) and alternatively polarized M2 macrophages, influence almost all types of
cancers by regulating diverse facets of immunosuppression, angiogenesis, cell proliferation, growth and metastasis. One-third
of Americans are obese, and accumulating evidence suggests that obesity is a risk factor for various cancers. However, the
relationship between these immune players and obesity are not well-described. In this review, we evaluate potential
mechanisms through which different aspects of obesity, namely insulin resistance, increased estrogen, adiposity and low grade
chronic inflammation from adipose tissue macrophages, may coalesce to promote MDSC induction and M2 macrophage
polarization, thereby facilitating cancer development. Detailed understanding of the interplay between obesity and myeloid
mediated immunosuppression may provide novel avenues for therapeutic targeting, with the goal to reduce the challenge
obesity presents towards gains made in cancer outcomes. (ajcr0000164).
Keywords: Obesity, inflammation, myeloid derived suppressor cells, alternately activated macrophage, cancer
Address all correspondence to:
Dr. Roberto Diaz
Department of Radiation Oncology
Winship Cancer Institute
Emory University School of Medicine
Atlanta, GA 30322, USA.
Phone: (404) 7783473; Fax: (404) 7785520
E-mail: roberto.diaz@emory.edu
Review Article
Obesity-driven inflammation and cancer risk: role of myeloid derived
suppressor cells and alternately activated macrophages
Derick Okwan-Duodu, Guillermo E Umpierrez, Otis W Brawley, Roberto Diaz
Department of Radiation Oncology, Medicine, Hematology and Medical Oncology, Emory University School of Medicine, Atlanta
GA USA 30322
Received December 5, 2012; Accepted December 23, 2012; Epub January 18, 2013; Published January 25, 2013
Abstract: During carcinogenesis, tumors induce dysfunctional development of hematopoietic cells. Myeloid lineage cells, in the
form of myeloid derived suppressor cells (MDSCs) and alternatively polarized M2 macrophages, influence almost all types of
cancers by regulating diverse facets of immunosuppression, angiogenesis, cell proliferation, growth and metastasis. One-third
of Americans are obese, and accumulating evidence suggests that obesity is a risk factor for various cancers. However, the
relationship between these immune players and obesity are not well-described. In this review, we evaluate potential
mechanisms through which different aspects of obesity, namely insulin resistance, increased estrogen, adiposity and low grade
chronic inflammation from adipose tissue macrophages, may coalesce to promote MDSC induction and M2 macrophage
polarization, thereby facilitating cancer development. Detailed understanding of the interplay between obesity and myeloid
mediated immunosuppression may provide novel avenues for therapeutic targeting, with the goal to reduce the challenge
obesity presents towards gains made in cancer outcomes. (ajcr0000164).
Keywords: Obesity, inflammation, myeloid derived suppressor cells, alternately activated macrophage, cancer
Address all correspondence to:
Dr. Roberto Diaz
Department of Radiation Oncology
Winship Cancer Institute
Emory University School of Medicine
Atlanta, GA 30322, USA.
Phone: (404) 7783473; Fax: (404) 7785520
E-mail: roberto.diaz@emory.edu
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American Journal of Cancer Research
| ISSN: 2156-6976 |