Am J Cancer Res 2013;3(3):240-250
Review Article
Mouse models for colorectal cancer
Baktiar O Karim, David L Huso
Department of Molecular and Comparative Pathobiology, The Johns Hopkins University, Baltimore, MD 21205, USA
Received April 10, 2013; Accepted May 23, 2013; Epub June 20, 2013; Published June 30, 2013
Abstract: Colorectal cancer (CRC) is the third leading cause of cancer-related death in the United States, with the number of
affected people increasing. There are many risk factors that increase CRC risk, including family or personal history of CRC,
smoking, consumption of red meat, obesity, and alcohol consumption. Conversely, increased screening, maintaining healthy
body weight, not smoking, and limiting intake of red meat are all associated with reduced CRC morbidity and mortality. Mouse
models of CRC were first used in 1928 and have played an important role in understanding CRC biology and treatment and
have long been instrumental in clarifying the pathobiology of CRC formation and inhibition. This review focuses on
advancements in modeling CRC in mice. (ajcr0000196).
Keywords: Colorectal cancer, human, mouse models, tumorigenesis, Apc, FAP, HNPCC, stem cells
Address correspondence to: Dr. Baktiar O Karim, Department of Molecular and Comparative Pathobiology, The Johns Hopkins
University, 733 N. Broadway, Office #849, Baltimore, MD 21205, USA. E-mail: bkarim@jhmi.edu
Review Article
Mouse models for colorectal cancer
Baktiar O Karim, David L Huso
Department of Molecular and Comparative Pathobiology, The Johns Hopkins University, Baltimore, MD 21205, USA
Received April 10, 2013; Accepted May 23, 2013; Epub June 20, 2013; Published June 30, 2013
Abstract: Colorectal cancer (CRC) is the third leading cause of cancer-related death in the United States, with the number of
affected people increasing. There are many risk factors that increase CRC risk, including family or personal history of CRC,
smoking, consumption of red meat, obesity, and alcohol consumption. Conversely, increased screening, maintaining healthy
body weight, not smoking, and limiting intake of red meat are all associated with reduced CRC morbidity and mortality. Mouse
models of CRC were first used in 1928 and have played an important role in understanding CRC biology and treatment and
have long been instrumental in clarifying the pathobiology of CRC formation and inhibition. This review focuses on
advancements in modeling CRC in mice. (ajcr0000196).
Keywords: Colorectal cancer, human, mouse models, tumorigenesis, Apc, FAP, HNPCC, stem cells
Address correspondence to: Dr. Baktiar O Karim, Department of Molecular and Comparative Pathobiology, The Johns Hopkins
University, 733 N. Broadway, Office #849, Baltimore, MD 21205, USA. E-mail: bkarim@jhmi.edu
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American Journal of Cancer Research
| ISSN: 2156-6976 |